The Gnomad Genetics MCP Server MCP server,
connected in one click.

gnomad_get_variant — Fetch the full gnomAD population record for one or more variants — allele count/number/frequency overall and broken down per genetic-ancestr

gnomad_get_gene_constraint — Fetch gnomAD loss-of-function constraint for a gene — pLI (probability of LoF intolerance; >0.9 intolerant), LOEUF (oe_lof_upper, the headli

gnomad_list_gene_variants — List every gnomAD variant in a gene, transcript, or region with allele frequencies and predicted consequences, optionally filtered to one co

gnomad_get_coverage — Fetch gnomAD sequencing-coverage summary across a gene, transcript, or region — mean and median read depth, plus the mean fraction of sample

gnomad_search_clinvar — Search ClinVar (NCBI E-utilities) for a gene and return its classified variants — clinical significance, review status with a 0–4 star ratin

gnomad_dataframe_query — Run a read-only SQL SELECT against a canvas table staged by gnomad_list_gene_variants (table gene_variants) or gnomad_search_clinvar (table

gnomad_dataframe_describe — List the tables staged on a canvas and their columns (name and type) so you can write correct SQL for gnomad_dataframe_query. Use the canvas